diff --git a/python/tvm/relax/frontend/onnx/onnx_frontend.py b/python/tvm/relax/frontend/onnx/onnx_frontend.py
index 7d85906cffdd..3cb1ab6756ad 100644
--- a/python/tvm/relax/frontend/onnx/onnx_frontend.py
+++ b/python/tvm/relax/frontend/onnx/onnx_frontend.py
@@ -2327,6 +2327,72 @@ def _normalize_constant_axes(axes: list[int], rank: int, op_name: str) -> list[i
     return normalized_axes
 
 
+def _try_get_static_int(value: int | tirx.PrimExpr) -> int | None:
+    """Return a Python int for statically known integer values."""
+
+    if isinstance(value, int):
+        return value
+    if isinstance(value, tirx.IntImm):
+        return int(value.value)
+    return None
+
+
+def _get_static_tensor_dim(expr: relax.Expr, axis: int) -> int | None:
+    """Return a statically known tensor dimension when available."""
+
+    if isinstance(expr, relax.Constant):
+        return int(expr.data.numpy().shape[axis])
+
+    struct_info = expr.struct_info
+    if not isinstance(struct_info, relax.TensorStructInfo):
+        return None
+    if not isinstance(struct_info.shape, relax.ShapeExpr):
+        return None
+    return _try_get_static_int(struct_info.shape.values[axis])
+
+
+def _canonicalize_onnx_slice_index(index: int, dim: int, step: int, is_start: bool) -> int:
+    """Canonicalize a Slice bound using ONNX's static clamp rules."""
+
+    if index < 0:
+        index += dim
+
+    lower_bound = 0
+    upper_bound = dim
+    if step < 0:
+        lower_bound = 0 if is_start else -1
+        upper_bound = dim - 1
+
+    return min(max(index, lower_bound), upper_bound)
+
+
+def _normalize_empty_constant_slice_ranges(
+    data: relax.Expr,
+    axes: list[int],
+    starts: list[int | tirx.PrimExpr],
+    ends: list[int | tirx.PrimExpr],
+    steps: list[int | tirx.PrimExpr],
+) -> list[int | tirx.PrimExpr]:
+    """Normalize statically empty ONNX Slice ranges for Relax strided_slice."""
+
+    normalized_ends = list(ends)
+    for i, axis in enumerate(axes):
+        start = _try_get_static_int(starts[i])
+        end = _try_get_static_int(ends[i])
+        step = _try_get_static_int(steps[i])
+        dim = _get_static_tensor_dim(data, axis)
+        if start is None or end is None or step is None or dim is None:
+            continue
+
+        start = _canonicalize_onnx_slice_index(start, dim, step, is_start=True)
+        end = _canonicalize_onnx_slice_index(end, dim, step, is_start=False)
+        is_empty = start >= end if step > 0 else start <= end
+        if is_empty:
+            normalized_ends[i] = starts[i]
+
+    return normalized_ends
+
+
 def _as_int64_tensor(bb: relax.BlockBuilder, expr: relax.Expr) -> relax.Expr:
     """Convert a tensor-like expression to an int64 tensor expression."""
 
@@ -2490,6 +2556,7 @@ def _impl_v13(cls, bb, inputs, attr, params):
             assume_inbound = not all(
                 [isinstance(param, tirx.IntImm | int) for param in [*starts, *ends, *steps]]
             )
+            ends = _normalize_empty_constant_slice_ranges(data, axes, starts, ends, steps)
             starts = get_prim_value_list(starts)
             ends = get_prim_value_list(ends)
             steps = get_prim_value_list(steps)
diff --git a/tests/python/relax/test_frontend_onnx.py b/tests/python/relax/test_frontend_onnx.py
index 52a4064cc8f5..5b73ec35183f 100644
--- a/tests/python/relax/test_frontend_onnx.py
+++ b/tests/python/relax/test_frontend_onnx.py
@@ -2916,6 +2916,7 @@ def verify_slice(data_shape, output_shape, starts, ends, axes=None, steps=None):
         steps=[-1, -3, -2],
         axes=[0, 1, 2],
     )
+    verify_slice([10], [0], starts=[0], ends=[5], axes=[0], steps=[-1])
     verify_slice([20, 10, 5], [10, 5], starts=[0, 0], ends=[3, 10], axes=[1, 2])
     verify_slice([20, 10, 5], [10, 5], starts=[0, 0], ends=[3, 10], axes=[1, 2])