diff --git a/codegen/opentelemetry-codegen-json/test-requirements.txt b/codegen/opentelemetry-codegen-json/test-requirements.txt
index 54a16dc30e0..822b8e6881e 100644
--- a/codegen/opentelemetry-codegen-json/test-requirements.txt
+++ b/codegen/opentelemetry-codegen-json/test-requirements.txt
@@ -1,7 +1,7 @@
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.5.0
-protobuf==6.31.1
+protobuf==6.33.5
 pytest==7.4.4
 tomli==2.0.1
 typing_extensions==4.12.0
diff --git a/docs/examples/fork-process-model/flask-gunicorn/requirements.txt b/docs/examples/fork-process-model/flask-gunicorn/requirements.txt
index de4cc15ee56..43e9829bfd4 100644
--- a/docs/examples/fork-process-model/flask-gunicorn/requirements.txt
+++ b/docs/examples/fork-process-model/flask-gunicorn/requirements.txt
@@ -12,7 +12,7 @@ opentelemetry-instrumentation==0.41b0
 opentelemetry-instrumentation-flask==0.41b0
 opentelemetry-instrumentation-wsgi==0.41b0
 opentelemetry-sdk==1.20.0
-protobuf==3.20.3
+protobuf==6.33.5
 six==1.15.0
 thrift==0.13.0
 uWSGI==2.0.22
diff --git a/docs/examples/fork-process-model/flask-uwsgi/requirements.txt b/docs/examples/fork-process-model/flask-uwsgi/requirements.txt
index 6bf12485c59..d07b18e01b0 100644
--- a/docs/examples/fork-process-model/flask-uwsgi/requirements.txt
+++ b/docs/examples/fork-process-model/flask-uwsgi/requirements.txt
@@ -11,7 +11,7 @@ opentelemetry-instrumentation==0.41b0
 opentelemetry-instrumentation-flask==0.41b0
 opentelemetry-instrumentation-wsgi==0.41b0
 opentelemetry-sdk==1.20.0
-protobuf==3.20.3
+protobuf==6.33.5
 six==1.15.0
 thrift==0.13.0
 uWSGI==2.0.22
diff --git a/docs/examples/metrics/prometheus-grafana/requirements.txt b/docs/examples/metrics/prometheus-grafana/requirements.txt
index f18ff7b7b48..63799ddb8c5 100644
--- a/docs/examples/metrics/prometheus-grafana/requirements.txt
+++ b/docs/examples/metrics/prometheus-grafana/requirements.txt
@@ -1,2 +1,2 @@
 opentelemetry-exporter-prometheus==1.12.0rc1
-protobuf~=3.18.1
+protobuf~=3.20.3
diff --git a/exporter/opentelemetry-exporter-opencensus/test-requirements.txt b/exporter/opentelemetry-exporter-opencensus/test-requirements.txt
index 72f4636db05..b220b08f5de 100644
--- a/exporter/opentelemetry-exporter-opencensus/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-opencensus/test-requirements.txt
@@ -4,7 +4,7 @@ iniconfig==2.0.0
 opencensus-proto==0.1.0
 packaging==24.0
 pluggy==1.6.0
-protobuf==3.20.3
+protobuf==6.33.5
 py-cpuinfo==9.0.0
 pytest==7.4.4
 tomli==2.0.1
diff --git a/exporter/opentelemetry-exporter-otlp-json-common/test-requirements.txt b/exporter/opentelemetry-exporter-otlp-json-common/test-requirements.txt
index 45c1ed33c25..ebbbb38e386 100644
--- a/exporter/opentelemetry-exporter-otlp-json-common/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-otlp-json-common/test-requirements.txt
@@ -2,7 +2,7 @@ asgiref==3.7.2
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.6.0
-protobuf==6.31.1
+protobuf==6.33.5
 py-cpuinfo==9.0.0
 pytest==7.4.4
 tomli==2.0.1
diff --git a/exporter/opentelemetry-exporter-zipkin-proto-http/test-requirements.txt b/exporter/opentelemetry-exporter-zipkin-proto-http/test-requirements.txt
index 56edd9fba2e..d00705a9839 100644
--- a/exporter/opentelemetry-exporter-zipkin-proto-http/test-requirements.txt
+++ b/exporter/opentelemetry-exporter-zipkin-proto-http/test-requirements.txt
@@ -5,7 +5,7 @@ idna==3.7
 iniconfig==2.0.0
 packaging==24.0
 pluggy==1.6.0
-protobuf==3.20.3
+protobuf==6.33.5
 py-cpuinfo==9.0.0
 pytest==7.4.4
 requests==2.32.3
diff --git a/shim/opentelemetry-opencensus-shim/test-requirements.txt b/shim/opentelemetry-opencensus-shim/test-requirements.txt
index 1f151ed6b3b..cedfc312cbf 100644
--- a/shim/opentelemetry-opencensus-shim/test-requirements.txt
+++ b/shim/opentelemetry-opencensus-shim/test-requirements.txt
@@ -13,7 +13,7 @@ opencensus-context==0.1.3
 opencensus-proto==0.1.0
 packaging==24.0
 pluggy==1.6.0
-protobuf==3.20.3
+protobuf==6.33.5
 py-cpuinfo==9.0.0
 pyasn1==0.5.1
 pyasn1-modules==0.3.0