diff --git a/changelog/14795.bugfix.rst b/changelog/14795.bugfix.rst
new file mode 100644
index 00000000000..337e6727655
--- /dev/null
+++ b/changelog/14795.bugfix.rst
@@ -0,0 +1 @@
+Handle non-tuple and non-list parameter items cleanly in :meth:`ParameterSet.extract_from` when single parameter names use trailing commas in :func:`pytest.mark.parametrize`.
diff --git a/src/_pytest/mark/structures.py b/src/_pytest/mark/structures.py
index 5449b17a1c6..488ceebc0a2 100644
--- a/src/_pytest/mark/structures.py
+++ b/src/_pytest/mark/structures.py
@@ -154,13 +154,10 @@ def extract_from(
             return parameterset
         if force_tuple:
             return cls.param(parameterset)
+        elif isinstance(parameterset, (tuple, list)):
+            return cls(parameterset, marks=[], id=None)
         else:
-            # TODO: Refactor to fix this type-ignore. Currently the following
-            # passes type-checking but crashes:
-            #
-            #   @pytest.mark.parametrize(('x', 'y'), [1, 2])
-            #   def test_foo(x, y): pass
-            return cls(parameterset, marks=[], id=None)  # type: ignore[arg-type]
+            return cls((parameterset,), marks=[], id=None)
 
     @staticmethod
     def _parse_parametrize_args(