diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index 042604ed7c1a42..2725f0089baba2 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -4254,6 +4254,19 @@ def meth(self):
         self.assertEqual(frozenset(typing._get_protocol_attrs(PG)),
                          frozenset({'x', 'meth'}))
 
+    def test_protocol_with_annotate_method_does_not_crash(self):
+        # gh-146643: defining a Protocol whose member is named __annotate__
+        # (a reserved name whose value is not a usable annotate function)
+        # used to crash protocol attribute collection with a TypeError.
+        class CanAnnotate(Protocol):
+            def __annotate__(self, format, /): ...
+
+        self.assertIs(CanAnnotate._is_protocol, True)
+        # __annotate__ is an excluded special name, so it is not collected as
+        # a protocol member, but creating the class must not raise.
+        self.assertNotIn('__annotate__',
+                         typing._get_protocol_attrs(CanAnnotate))
+
     def test_no_runtime_deco_on_nominal(self):
         with self.assertRaises(TypeError):
             @runtime_checkable
diff --git a/Lib/typing.py b/Lib/typing.py
index 1579f492003f74..16227c0f445bd5 100644
--- a/Lib/typing.py
+++ b/Lib/typing.py
@@ -1874,9 +1874,16 @@ def _get_protocol_attrs(cls):
             annotations = base.__annotations__
         except Exception:
             # Only go through annotationlib to handle deferred annotations if we need to
-            annotations = annotationlib.get_annotations(
-                base, format=annotationlib.Format.FORWARDREF
-            )
+            try:
+                annotations = annotationlib.get_annotations(
+                    base, format=annotationlib.Format.FORWARDREF
+                )
+            except Exception:
+                # The annotations cannot be retrieved at all, e.g. the base
+                # defines an ``__annotate__`` member that is not a usable
+                # annotate function (gh-146643).  Treat it as un-annotated
+                # rather than letting the class definition fail.
+                annotations = {}
         for attr in (*base.__dict__, *annotations):
             if not attr.startswith('_abc_') and attr not in EXCLUDED_ATTRIBUTES:
                 attrs.add(attr)
diff --git a/Misc/NEWS.d/next/Library/2026-06-22-14-15-00.gh-issue-146643.Lm5wTq.rst b/Misc/NEWS.d/next/Library/2026-06-22-14-15-00.gh-issue-146643.Lm5wTq.rst
new file mode 100644
index 00000000000000..868837df2ac605
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2026-06-22-14-15-00.gh-issue-146643.Lm5wTq.rst
@@ -0,0 +1,3 @@
+Fix a :exc:`TypeError` raised when defining a :class:`typing.Protocol` whose
+body (or one of its bases) declares a member named ``__annotate__`` that is not
+a usable annotate function.  Such a class can now be created without error.