diff --git a/CHANGELOG.markdown b/CHANGELOG.markdown
index b25e822c..4b0f4f80 100644
--- a/CHANGELOG.markdown
+++ b/CHANGELOG.markdown
@@ -1,5 +1,7 @@
 # Pending
 
+- Fix compatibility with `http >= 6.0.0` (#613)
+
 # 6.1.1
 
 - Fix Redis 5 prepend interaction (#611)
diff --git a/lib/scout_apm/instruments/http.rb b/lib/scout_apm/instruments/http.rb
index b8c6d70e..b6ae02d0 100644
--- a/lib/scout_apm/instruments/http.rb
+++ b/lib/scout_apm/instruments/http.rb
@@ -24,30 +24,63 @@ def install(prepend:)
 
           if prepend
             ::HTTP::Client.send(:include, ScoutApm::Tracer)
-            ::HTTP::Client.send(:prepend, HTTPInstrumentationPrepend)
+            if http_version_at_least?("6.0.0")
+              ::HTTP::Client.send(:prepend, HTTPInstrumentationPrependV6)
+            else
+              ::HTTP::Client.send(:prepend, HTTPInstrumentationPrepend)
+            end
           else
-            ::HTTP::Client.class_eval do
-              include ScoutApm::Tracer
+            if http_version_at_least?("6.0.0")
+              ::HTTP::Client.class_eval do
+                include ScoutApm::Tracer
 
-              def request_with_scout_instruments(verb, uri, opts = {})
-                self.class.instrument("HTTP", verb, :ignore_children => true, :desc => request_scout_description(verb, uri)) do
-                  request_without_scout_instruments(verb, uri, opts)
+                def request_with_scout_instruments(verb, uri, **opts)
+                  self.class.instrument("HTTP", verb, :ignore_children => true, :desc => request_scout_description(verb, uri)) do
+                    request_without_scout_instruments(verb, uri, **opts)
+                  end
+                end
+
+                def request_scout_description(verb, uri)
+                  max_length = ScoutApm::Agent.instance.context.config.value('instrument_http_url_length')
+                  (String(uri).split('?').first)[0..(max_length - 1)]
+                rescue
+                  ""
                 end
-              end
 
-              def request_scout_description(verb, uri)
-                max_length = ScoutApm::Agent.instance.context.config.value('instrument_http_url_length')
-                (String(uri).split('?').first)[0..(max_length - 1)]
-              rescue
-                ""
+                alias request_without_scout_instruments request
+                alias request request_with_scout_instruments
               end
+            else
+              ::HTTP::Client.class_eval do
+                include ScoutApm::Tracer
+
+                def request_with_scout_instruments(verb, uri, opts = {})
+                  self.class.instrument("HTTP", verb, :ignore_children => true, :desc => request_scout_description(verb, uri)) do
+                    request_without_scout_instruments(verb, uri, opts)
+                  end
+                end
 
-              alias request_without_scout_instruments request
-              alias request request_with_scout_instruments
+                def request_scout_description(verb, uri)
+                  max_length = ScoutApm::Agent.instance.context.config.value('instrument_http_url_length')
+                  (String(uri).split('?').first)[0..(max_length - 1)]
+                rescue
+                  ""
+                end
+
+                alias request_without_scout_instruments request
+                alias request request_with_scout_instruments
+              end
             end
           end
         end
       end
+
+      private
+
+      def http_version_at_least?(version)
+        defined?(::HTTP::VERSION) &&
+          Gem::Version.new(::HTTP::VERSION) >= Gem::Version.new(version)
+      end
     end
 
     module HTTPInstrumentationPrepend
@@ -64,5 +97,20 @@ def request_scout_description(verb, uri)
         ""
       end
     end
+
+    module HTTPInstrumentationPrependV6
+      def request(verb, uri, **opts)
+        self.class.instrument("HTTP", verb, :ignore_children => true, :desc => request_scout_description(verb, uri)) do
+          super(verb, uri, **opts)
+        end
+      end
+
+      def request_scout_description(verb, uri)
+        max_length = ScoutApm::Agent.instance.context.config.value('instrument_http_url_length')
+        (String(uri).split('?').first)[0..(max_length - 1)]
+      rescue
+        ""
+      end
+    end
   end
 end
diff --git a/test/unit/instruments/http_test.rb b/test/unit/instruments/http_test.rb
index 6fdc9703..1e50b726 100644
--- a/test/unit/instruments/http_test.rb
+++ b/test/unit/instruments/http_test.rb
@@ -15,9 +15,14 @@ def setup
 
     def test_installs_using_proper_method
       if @instrument_manager.prepend_for_instrument?(@instance.class) == true
-        assert ::HTTP::Client.ancestors.include?(ScoutApm::Instruments::HTTPInstrumentationPrepend)
+        if Gem::Version.new(::HTTP::VERSION) >= Gem::Version.new("6.0.0")
+          assert ::HTTP::Client.ancestors.include?(ScoutApm::Instruments::HTTPInstrumentationPrependV6)
+        else
+          assert ::HTTP::Client.ancestors.include?(ScoutApm::Instruments::HTTPInstrumentationPrepend)
+        end
       else
         assert_equal false, ::HTTP::Client.ancestors.include?(ScoutApm::Instruments::HTTPInstrumentationPrepend)
+        assert_equal false, ::HTTP::Client.ancestors.include?(ScoutApm::Instruments::HTTPInstrumentationPrependV6)
       end
     end
   end