diff --git a/.github/workflows/sanitizers.yml b/.github/workflows/sanitizers.yml
new file mode 100644
index 000000000..da585bf2d
--- /dev/null
+++ b/.github/workflows/sanitizers.yml
@@ -0,0 +1,98 @@
+name: Sanitizers
+on:
+  workflow_dispatch:
+  pull_request:
+  push:
+    branches: [master]
+concurrency:
+  group: ${{ github.workflow }}-${{ github.job }}-${{ github.ref }}
+  cancel-in-progress: true
+defaults:
+  run:
+    shell: bash -e -l {0}
+jobs:
+  build:
+    runs-on: ${{ matrix.os }}
+    name: sanitizer / ${{ matrix.sys.compiler }} ${{ matrix.sys.version }} / ${{ matrix.config.name }} / ${{ matrix.sys.name }}
+    strategy:
+      fail-fast: false
+      matrix:
+        os: [ubuntu-24.04]
+        sys:
+        - {compiler: clang, version: '19', name: asan}
+        - {compiler: clang, version: '21', name: asan}
+        config:
+        - {name: Debug}
+
+    steps:
+
+    - name: Install LLVM and Clang
+      if: matrix.sys.compiler == 'clang'
+      run: |
+        wget https://apt.llvm.org/llvm.sh
+        chmod +x llvm.sh
+        sudo ./llvm.sh ${{matrix.sys.version}}
+        sudo apt-get install -y clang-tools-${{matrix.sys.version}}
+        sudo update-alternatives --install /usr/bin/clang++         clang++             /usr/bin/clang++-${{matrix.sys.version}} 200
+        sudo update-alternatives --install /usr/bin/clang           clang               /usr/bin/clang-${{matrix.sys.version}} 200
+        sudo update-alternatives --install /usr/bin/clang-scan-deps clang-scan-deps     /usr/bin/clang-scan-deps-${{matrix.sys.version}} 200
+        sudo update-alternatives --set clang /usr/bin/clang-${{matrix.sys.version}}
+        sudo update-alternatives --set clang++ /usr/bin/clang++-${{matrix.sys.version}}
+        sudo update-alternatives --set clang-scan-deps /usr/bin/clang-scan-deps-${{matrix.sys.version}}
+
+    - name: Checkout code
+      uses: actions/checkout@v6
+
+    - name: Set conda environment
+      uses: mamba-org/setup-micromamba@main
+      with:
+        environment-name: myenv
+        environment-file: environment-dev.yml
+        init-shell: bash
+        cache-downloads: true
+
+    - name: Configure using CMake
+      run: |
+        export CC=clang
+        export CXX=clang++
+        cmake -G Ninja \
+          -Bbuild \
+          -DCMAKE_BUILD_TYPE=${{matrix.config.name}} \
+          -DCMAKE_INSTALL_PREFIX=$CONDA_PREFIX \
+          -DBUILD_TESTS=ON \
+          -DUSE_SANITIZER=address
+
+    - name: Build tests
+      working-directory: build
+      run: cmake --build . --config ${{matrix.config.name}} --target test_xtensor_lib --parallel 8
+
+    - name: Run tests
+      working-directory: build
+      run: |
+        export ASAN_OPTIONS=log_path=asan_log_:alloc_dealloc_mismatch=0:halt_on_error=0:handle_abort=0
+        export ASAN_SAVE_DUMPS=AsanDump.dmp
+        ctest -R ^xtest$ --output-on-failure
+
+    - name: Upload ASAN log
+      if: always()
+      uses: actions/upload-artifact@v6
+      with:
+        name: asan-log-${{ matrix.sys.compiler }}-${{ matrix.sys.version }}-${{ matrix.config.name }}-${{ runner.os }}
+        path: '**/asan_log_*'
+        if-no-files-found: ignore
+
+    - name: Upload ASAN dump
+      if: always()
+      uses: actions/upload-artifact@v6
+      with:
+        name: asan-dump-${{ matrix.sys.compiler }}-${{ matrix.sys.version }}-${{ matrix.config.name }}-${{ runner.os }}
+        path: '**/AsanDump.dmp'
+        if-no-files-found: ignore
+
+    - name: Return errors if ASAN log content is not empty
+      if: always()
+      run: |
+        if [ -n "$(find build/test -name 'asan_log_*' -type f -size +0 2>/dev/null)" ]; then
+          echo "ASAN detected errors. See the log for details."
+          exit 1
+        fi
diff --git a/cmake/sanitizers.cmake b/cmake/sanitizers.cmake
new file mode 100644
index 000000000..716021f96
--- /dev/null
+++ b/cmake/sanitizers.cmake
@@ -0,0 +1,47 @@
+set(AVALAIBLE_SANITIZERS "address;leak;memory;thread;undefined")
+OPTION(USE_SANITIZER "Enable sanitizer(s). Options are: ${AVALAIBLE_SANITIZERS}. Case insensitive; multiple options delimited by comma or space possible." "")
+string(TOLOWER "${USE_SANITIZER}" USE_SANITIZER)
+
+if((CMAKE_BUILD_TYPE IN_LIST "Debug;RelWithDebInfo") AND USE_SANITIZER)
+    message(FATAL_ERROR "❌ Sanitizer only supported in Debug and RelWithDebInfo build types.")
+endif()
+
+if(USE_SANITIZER)
+    if(CMAKE_CXX_COMPILER_ID STREQUAL "MSVC")
+        set(CMAKE_MSVC_DEBUG_INFORMATION_FORMAT "$<IF:$<AND:$<C_COMPILER_ID:MSVC>,$<CXX_COMPILER_ID:MSVC>>,$<$<CONFIG:Debug,RelWithDebInfo>:EditAndContinue>,$<$<CONFIG:Debug,RelWithDebInfo>:ProgramDatabase>>")
+
+        if(USE_SANITIZER MATCHES "address")
+            list(APPEND SANITIZER_COMPILE_OPTIONS /fsanitize=address /D_DISABLE_VECTOR_ANNOTATION /D_DISABLE_STRING_ANNOTATION)
+        else()
+            message(FATAL_ERROR "❌ Sanitizer not supported by MSVC: ${USE_SANITIZER}. It only supports 'address'.")
+        endif()
+    elseif(CMAKE_CXX_COMPILER_ID STREQUAL "Clang" AND CMAKE_CXX_COMPILER_FRONTEND_VARIANT STREQUAL "MSVC")
+        if(USE_SANITIZER MATCHES "address")
+            list(APPEND SANITIZER_COMPILE_OPTIONS /fsanitize=address /D_DISABLE_VECTOR_ANNOTATION /D_DISABLE_STRING_ANNOTATION)
+            list(APPEND SANITIZER_LINK_LIBRARIES clang_rt.asan_dynamic-x86_64 clang_rt.asan_dynamic_runtime_thunk-x86_64)
+        else()
+            message(FATAL_ERROR "❌ Sanitizer not supported by Clang-MSVC: ${USE_SANITIZER}. It only supports 'address'.")
+        endif()
+    elseif(CMAKE_CXX_COMPILER_ID STREQUAL "Clang" OR CMAKE_CXX_COMPILER_ID STREQUAL "AppleClang" OR CMAKE_CXX_COMPILER_ID STREQUAL "GNU")
+        foreach(sanitizer ${USE_SANITIZER})
+            if(NOT ${sanitizer} IN_LIST AVALAIBLE_SANITIZERS)
+                message(FATAL_ERROR "❌ Sanitizer not supported: ${sanitizer}. It should be one of: ${AVALAIBLE_SANITIZERS}.")
+            endif()
+            list(APPEND SANITIZER_COMPILE_OPTIONS -fsanitize=${sanitizer})
+            list(APPEND SANITIZER_LINK_OPTIONS -fsanitize=${sanitizer})
+            if (${sanitizer} MATCHES "memory")
+                list(APPEND SANITIZER_LINK_LIBRARIES -fsanitize-memory-track-origins -fPIE -pie)
+                list(APPEND SANITIZER_LINK_OPTIONS -fsanitize-memory-track-origins -fPIE -pie)
+            endif()
+        endforeach()
+        list(APPEND SANITIZER_COMPILE_OPTIONS -fno-omit-frame-pointer)
+    else()
+        message(FATAL_ERROR "❌ Sanitizer: Unsupported compiler: ${CMAKE_CXX_COMPILER_ID}")
+    endif()
+
+    list(REMOVE_DUPLICATES SANITIZER_COMPILE_OPTIONS)
+    list(REMOVE_DUPLICATES SANITIZER_LINK_OPTIONS)
+    list(REMOVE_DUPLICATES SANITIZER_LINK_LIBRARIES)
+
+    message(STATUS "🔍 Using sanitizer: ${USE_SANITIZER}")
+endif()
diff --git a/test/CMakeLists.txt b/test/CMakeLists.txt
index 8341230ee..deb7ddf22 100644
--- a/test/CMakeLists.txt
+++ b/test/CMakeLists.txt
@@ -231,6 +231,9 @@ endforeach()
 
 file(GLOB XTENSOR_PREPROCESS_FILES files/cppy_source/*.cppy)
 
+# Sanitizer support
+include(${CMAKE_SOURCE_DIR}/cmake/sanitizers.cmake)
+
 # This target should only be run when the test source files have been changed.
 add_custom_target(
     preprocess_cppy